LoL, not an English major. Edit…
Also there’s this survey that shows we actually would prefer stopping climate change instead of fighting war.
https://kbin.run/m/climate@slrpnk.net/t/505138/Most-people-in-petrostates-want-quick-switch-to-clean-energy
also for the strong of mind: https://pubmed.ncbi.nlm.nih.gov/
As a child, once I learned to read, I started to really learn. And naturally shared all the fun facts with most anyone who would listen. I thought I would write a book of fun facts, but then someone invented the Intarwebs. I even thought I would narrow things down and just write ‘Bandana, 1001 Uses’ , but there was no point. (https://duckduckgo.com/?t=ffab&q=bandana+uses+list&ia=web)
Actually we DID. Tho’ only for a little while. And the results were enormous. The B/Yamgata Influenza lineage appears to have gone extinct. The cool part is we weren’t even trying to do anything with those specific efforts to affect influenza. All of which should encourage us to cooperate more.
Mastodon Social awaits! https://joinmastodon.org/
No! Well, some idiot will. But not this idiot! Have you ever heard of Mastodon Social (https://mastodon.social/)?
https://joinmastodon.org/
I know one of those kids, early teen, has moved into cooking most of the family’s meals. I loved to cook as a kid, and still do. :-)
And did your parents pay $35 for the experience?
Pretty sure it wasn’t formal.
I’m thinking Toyota Hi-Lux EV.
Agreed! And yeah, still down, I just checked.
This is exactly why I’m not a gambler. ;-) I really prefer it when people say things like, “wow, thanks, here have a fiver.”
Dude’s a superhero, and needn’t be a ‘lone ranger’. Agreed. As the Fediverse expands, it will be the work of many; it just has to be that way.
MBIN FTW. KBIN has been “We are working on resolving the issues” for some days now. I hope Ernest is ok.
I have a login for lemmy.ml, as I have several from when I was switching over from Reddit. I’m thinking from what I’m reading here, that it’s not an instance I want to associate with.
A little chortle now and then. Keeps things from getting to ‘heavy’.
From the abstract: "By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. "
I guess you owe me five bucks.
It was her all along!
A disease-associated gene desert directs macrophage inflammation through ETS2 https://www.nature.com/articles/s41586-024-07501-1
Abstract
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug development2, highlighting an urgent need to better understand disease mechanisms. Here we show how functional genomics could address this challenge. By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. Genes regulated by ETS2 were prominently expressed in diseased tissues and more enriched for inflammatory bowel disease GWAS hits than most previously described pathways. Overexpressing ETS2 in resting macrophages reproduced the inflammatory state observed in chr21q22-associated diseases, with upregulation of multiple drug targets, including TNF and IL-23. Using a database of cellular signatures7, we identified drugs that might modulate this pathway and validated the potent anti-inflammatory activity of one class of small molecules in vitro and ex vivo. Together, this illustrates the power of functional genomics, applied directly in primary human cells, to identify immune-mediated disease mechanisms and potential therapeutic opportunities.
Anyone got a non-YT link? Or just the recipe? Something? TY in advance!!!